NCOA3 blocking peptide

NCOA3 Blocking Peptide (N-term)

• Gene Names: NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
• Synonyms: NCOA3; NCOA3 Blocking Peptide (N-term); Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1; AIB1; BHLHE42; RAC3; TRAM1; NCOA3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 359-372 of HUMAN NCOA3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1415

• Cellular Location: Cytoplasm. Nucleus. Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus
• Tissue Location: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NCOA3 blocking peptide

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

NCBI and Uniprot Product Information

• NCBI GI #: 291490685
• NCBI GeneID: 8202
• NCBI Accession #: NP_001167559.1
• NCBI GenBank Nucleotide #: NM_001174088.1
• UniProt Accession #: Q9Y6Q9; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; A4LAZ5
• Molecular Weight: 154,892 Da
• NCBI Official Full Name: nuclear receptor coactivator 3 isoform d
• NCBI Official Synonym Full Names: nuclear receptor coactivator 3
• NCBI Official Symbol: NCOA3
• NCBI Official Synonym Symbols: ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
• NCBI Protein Information: nuclear receptor coactivator 3
• UniProt Protein Name: Nuclear receptor coactivator 3
• Protein Family: Nuclear receptor coactivator
• UniProt Gene Name: NCOA3
• UniProt Synonym Gene Names: AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1
• UniProt Entry Name: NCOA3_HUMAN

NCBI Description

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Uniprot Description

SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Acetyltransferase; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis; EC 2.3.1.48; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity

Biological Process: intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter