MSRA blocking peptide

MSRA Antibody (N-term) Blocking Peptide

• Gene Names: MSRA; PMSR
• Synonyms: MSRA; MSRA Antibody (N-term) Blocking Peptide; Mitochondrial peptide methionine sulfoxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR; MSRA blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human MSRA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 235

• Cellular Location: Isoform 1: Mitochondrion. Isoform 3: Cytoplasm. Nucleus.
• Tissue Location: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MSRA blocking peptide

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

NCBI and Uniprot Product Information

• NCBI GI #: 12230350
• NCBI GeneID: 4482
• UniProt Accession #: Q9UJ68; Q52TC4; Q549N4; Q66MI7; E9PAS8
• Molecular Weight: 23,627 Da
• NCBI Official Full Name: Mitochondrial peptide methionine sulfoxide reductase
• NCBI Official Synonym Full Names: methionine sulfoxide reductase A
• NCBI Official Symbol: MSRA
• NCBI Official Synonym Symbols: PMSR
• NCBI Protein Information: mitochondrial peptide methionine sulfoxide reductase
• UniProt Protein Name: Mitochondrial peptide methionine sulfoxide reductase
• Protein Family: Mitochondrial peptide methionine sulfoxide reductase
• UniProt Gene Name: MSRA
• UniProt Synonym Gene Names: Peptide Met(O) reductase; PMSR
• UniProt Entry Name: MSRA_HUMAN

NCBI Description

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

MSRA: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Oxidoreductase; EC 1.8.4.11

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; nucleoplasm

Molecular Function: peptide-methionine-(S)-S-oxide reductase activity

Biological Process: methionine metabolic process; protein modification process; protein repair