Rabbit LHX4 Polyclonal Antibody | anti-LHX4 antibody

LHX4 Polyclonal Antibody

Cat. Num. AAA3009028

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: LHX4; Polyclonal Antibody; LHX4 Polyclonal Antibody; CPHD4; anti-LHX4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LHX4 polyclonal antibody detects endogenous levels of LHX4 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 390

• Applicable Applications for anti-LHX4 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human LHX4.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon carcinoma using LHX4 antibody at dilution of 1:100 (x400 lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human oophoroma using LHX4 antibody at dilution of 1:100 (x400 lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney cancer using LHX4 antibody at dilution of 1:100 (x400 lens).)

Related Product Information for anti-LHX4 antibody

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4.

NCBI and Uniprot Product Information

• NCBI GI #: 15375314
• NCBI Accession #: NP_203129.1
• NCBI GenBank Nucleotide #: NP_203129.1
• UniProt Accession #: Q969G2
• Molecular Weight: ~ 43kDa
• NCBI Official Full Name: LIM/homeobox protein Lhx4
• UniProt Protein Name: LIM/homeobox protein Lhx4
• Protein Family: LIM/homeobox protein
• UniProt Gene Name: LHX4
• UniProt Synonym Gene Names: LIM homeobox protein 4
• UniProt Entry Name: LHX4_HUMAN

Uniprot Description

LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: nucleus

Molecular Function: zinc ion binding; sequence-specific DNA binding

Biological Process: organ morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; medial motor column neuron differentiation; motor axon guidance; negative regulation of apoptosis; placenta development

Disease: Pituitary Hormone Deficiency, Combined, 4