MRAP blocking peptide

MRAP Antibody (N-term) Blocking Peptide

• Gene Names: MRAP; B27; FALP; FGD2; GCCD2; C21orf61
• Synonyms: MRAP; MRAP Antibody (N-term) Blocking Peptide; Melanocortin-2 receptor accessory protein; B27; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein; C21orf61; FALP; MRAP blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 172

• Cellular Location: Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771) Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm
• Tissue Location: Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MRAP blocking peptide

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

NCBI and Uniprot Product Information

• NCBI GI #: 116242634
• NCBI GeneID: 56246
• UniProt Accession #: Q8TCY5; Q5EBR3; Q8TDB7; Q8WXC1; Q8WXC2
• Molecular Weight: 12,338 Da
• NCBI Official Full Name: Melanocortin-2 receptor accessory protein
• NCBI Official Synonym Full Names: melanocortin 2 receptor accessory protein
• NCBI Official Symbol: MRAP
• NCBI Official Synonym Symbols: B27; FALP; FGD2; GCCD2; C21orf61
• NCBI Protein Information: melanocortin-2 receptor accessory protein
• UniProt Protein Name: Melanocortin-2 receptor accessory protein
• Protein Family: Melanocortin-2 receptor accessory protein
• UniProt Gene Name: MRAP
• UniProt Synonym Gene Names: C21orf61; FALP
• UniProt Entry Name: MRAP_HUMAN

NCBI Description

This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

Uniprot Description

MRAP: Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2); also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.1

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: adrenocorticotropin hormone receptor binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor binding

Biological Process: positive regulation of cAMP biosynthetic process

Disease: Glucocorticoid Deficiency 2