MEF2B blocking peptide

MEF2B Blocking Peptide

Cat. Num. AAA9623415

• Gene Names: MEF2B; RSRFR2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: MEF2B; MEF2B Blocking Peptide; MADS box transcription enhancer factor 2; MDS1 EVI1; Mef2b; MEF2B_HUMAN; Myocyte enhancer factor 2B; Myocyte specific enhancer factor 2B; Myocyte-specific enhancer factor 2B; PRDM3; RSRFR2; Serum response factor like protein 2; Serum response factor-like protein 2; XMEF2; MEF2B blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for MEF2B blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MEF2B blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 224809412
• NCBI GeneID: 100271849
• NCBI Accession #: NP_001139257.1
• NCBI GenBank Nucleotide #: NM_001145785.1
• UniProt Accession #: Q02080; A0AV80; B4DVH7; B7ZVY1; G5E9M1
• Molecular Weight: 38,639 Da
• NCBI Official Full Name: myocyte-specific enhancer factor 2B isoform a
• NCBI Official Synonym Full Names: myocyte enhancer factor 2B
• NCBI Official Symbol: MEF2B
• NCBI Official Synonym Symbols: RSRFR2
• NCBI Protein Information: myocyte-specific enhancer factor 2B; serum response factor-like protein 2; MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)
• UniProt Protein Name: Myocyte-specific enhancer factor 2B
• Protein Family: Myocyte-specific enhancer factor
• UniProt Gene Name: MEF2B
• UniProt Synonym Gene Names: XMEF2
• UniProt Entry Name: MEF2B_HUMAN

NCBI Description

The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207. [provided by RefSeq, Mar 2009]

Uniprot Description

MEF2B: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. Belongs to the MEF2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cell junction; nucleus

Molecular Function: protein dimerization activity; histone deacetylase binding; transcription factor activity

Biological Process: muscle development; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter