MCT1 (SLC16A1) Blocking Peptide | SLC16A1 blocking peptide

MCT1 (SLC16A1) Antibody (C-term) Blocking peptide

• Gene Names: SLC16A1; MCT; HHF7; MCT1; MCT1D
• Synonyms: MCT1 (SLC16A1); MCT1 (SLC16A1) Antibody (C-term) Blocking peptide; Monocarboxylate transporter 1; MCT 1; Solute carrier family 16 member 1; SLC16A1; MCT1; SLC16A1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SLC16A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 500

• Cellular Location: Cell membrane; Multi- pass membrane protein
• Tissue Location: Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC16A1 blocking peptide

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

NCBI and Uniprot Product Information

• NCBI GI #: 313104214
• NCBI GeneID: 6566
• UniProt Accession #: P53985; Q49A45; Q5T8R6; Q9NSJ9
• Molecular Weight: 46,234 Da
• NCBI Official Full Name: Monocarboxylate transporter 1
• NCBI Official Synonym Full Names: solute carrier family 16 member 1
• NCBI Official Symbol: SLC16A1
• NCBI Official Synonym Symbols: MCT; HHF7; MCT1; MCT1D
• NCBI Protein Information: monocarboxylate transporter 1
• UniProt Protein Name: Monocarboxylate transporter 1
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A1
• UniProt Synonym Gene Names: MCT1; MCT 1
• UniProt Entry Name: MOT1_HUMAN

NCBI Description

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Description

MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Mitochondrial; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: centrosome; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: lactate transmembrane transporter activity; mevalonate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity

Biological Process: centrosome organization and biogenesis; leukocyte migration; mevalonate transport; monocarboxylic acid transport; pyruvate metabolic process

Disease: Erythrocyte Lactate Transporter Defect; Hyperinsulinemic Hypoglycemia, Familial, 7; Monocarboxylate Transporter 1 Deficiency