CD104 recombinant protein

Recombinant Human CD104 protein, C-His Tag

Cat. Num. AAA1560566

• Gene Names: ITGB4; CD104
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD104; Recombinant Human CD104 protein; C-His Tag; ITGB4; CD104 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human ITGB4 (Met1-Ser710) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD104 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 54607035
• NCBI GeneID: 3691
• NCBI Accession #: NP_000204.3
• NCBI GenBank Nucleotide #: NM_000213.3
• UniProt Accession #: P16144; O14690; O14691; O15339; O15340; O15341; Q9UIQ4; A0AVL6
• Molecular Weight: 202,167 Da
• NCBI Official Full Name: integrin beta-4 isoform 1
• NCBI Official Synonym Full Names: integrin, beta 4
• NCBI Official Symbol: ITGB4
• NCBI Official Synonym Symbols: CD104
• NCBI Protein Information: integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit
• UniProt Protein Name: Integrin beta-4
• UniProt Gene Name: ITGB4
• UniProt Entry Name: ITB4_HUMAN

NCBI Description

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cell surface; hemidesmosome; leading edge; basal plasma membrane; plasma membrane; basement membrane; integrin complex; receptor complex

Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity

Biological Process: integrin-mediated signaling pathway; skin development; extracellular matrix organization and biogenesis; hemidesmosome assembly; filopodium formation; gut development; cell-matrix adhesion; response to wounding; cell motility involved in cell locomotion; mesodermal cell differentiation; autophagy; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia