Mavs blocking peptide

Mouse Mavs Blocking Peptide (N-term)

• Gene Names: Mavs; Visa; IPS-1; cardif; D430028G21Rik
• Synonyms: Mavs; Mouse Mavs Blocking Peptide (N-term); Mitochondrial antiviral-signaling protein; MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Virus-induced-signaling adapter; VISA; Ips1; Visa; Mavs blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 5-18 of MOUSE Mavs
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 503

• Cellular Location: Mitochondrion outer membrane. Mitochondrion. Peroxisome
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Mavs blocking peptide

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 21450263
• NCBI GeneID: 228607
• NCBI Accession #: NP_659137.1
• NCBI GenBank Nucleotide #: NM_144888.2
• UniProt Accession #: Q8VCF0
• Molecular Weight: 53,399 Da
• NCBI Official Full Name: mitochondrial antiviral-signaling protein isoform 1
• NCBI Official Synonym Full Names: mitochondrial antiviral signaling protein
• NCBI Official Symbol: Mavs
• NCBI Official Synonym Symbols: Visa; IPS-1; cardif; D430028G21Rik
• NCBI Protein Information: mitochondrial antiviral-signaling protein
• UniProt Protein Name: Mitochondrial antiviral-signaling protein
• Protein Family: Mitochondrial antiviral-signaling protein
• UniProt Gene Name: Mavs
• UniProt Synonym Gene Names: Ips1; Visa; MAVS; Cardif; IPS-1; VISA
• UniProt Entry Name: MAVS_MOUSE

Uniprot Description

MAVS: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Present in T-cells, monocytes, epithelial cells and hepatocytes. Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral

Cellular Component: mitochondrial membrane; mitochondrial outer membrane; mitochondrion; peroxisomal membrane; peroxisome

Molecular Function: CARD domain binding; protein binding; protein kinase binding; signal transducer activity

Biological Process: activation of innate immune response; defense response to bacterium; defense response to virus; innate immune response; negative regulation of viral genome replication; positive regulation of defense response to virus by host; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-8 production; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor activity; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; signal transduction