LIPI blocking peptide

LIPI Blocking Peptide (Center)

• Gene Names: LIPI; CT17; LPDL; PLA1C; PRED5; mPA-PLA1 beta
• Synonyms: LIPI; LIPI Blocking Peptide (Center); Lipase member I; 311-; Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta; LPDL; LIPI blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 224-238 of HUMAN LIPI
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 460

• Cellular Location: Isoform 1: Membrane. Secreted. Note: May associate with lipid draft
• Tissue Location: Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LIPI blocking peptide

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

NCBI and Uniprot Product Information

• NCBI GI #: 81170675
• NCBI GeneID: 149998
• UniProt Accession #: Q6XZB0; G1JSG3; G1JSG4; G1JSG5; G1JSG6; G1JSG7; G1JSG8; G1JSG9
• Molecular Weight: 34,110 Da
• NCBI Official Full Name: Lipase member I
• NCBI Official Synonym Full Names: lipase I
• NCBI Official Symbol: LIPI
• NCBI Official Synonym Symbols: CT17; LPDL; PLA1C; PRED5; mPA-PLA1 beta
• NCBI Protein Information: lipase member I
• UniProt Protein Name: Lipase member I
• Protein Family: Lipase
• UniProt Gene Name: LIPI
• UniProt Synonym Gene Names: LPDL; LIPI; CT17; mPA-PLA1 beta
• UniProt Entry Name: LIPI_HUMAN

NCBI Description

The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

LIPI: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Secreted, signal peptide; Secreted; Phospholipase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 21q11.2

Cellular Component: plasma membrane

Molecular Function: heparin binding; phospholipase activity

Biological Process: lipid catabolic process; lipid digestion

Disease: Hypertriglyceridemia, Familial