LAT2 blocking peptide

LAT2 Antibody (Center) Blocking Peptide

• Gene Names: LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• Synonyms: LAT2; LAT2 Antibody (Center) Blocking Peptide; Linker for activation of T-cells family member 2; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; LAB; NTAL; WBS15; WBSCR15; WBSCR5; LAT2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 243

• Cellular Location: Cell membrane; Single-pass type III membrane protein. Note: Present in lipid rafts
• Tissue Location: Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LAT2 blocking peptide

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

NCBI and Uniprot Product Information

• NCBI GI #: 74752543
• NCBI GeneID: 7462
• UniProt Accession #: Q9GZY6; Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9
• Molecular Weight: 12,255 Da
• NCBI Official Full Name: Linker for activation of T-cells family member 2
• NCBI Official Synonym Full Names: linker for activation of T-cells family member 2
• NCBI Official Symbol: LAT2
• NCBI Official Synonym Symbols: LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• NCBI Protein Information: linker for activation of T-cells family member 2
• UniProt Protein Name: Linker for activation of T-cells family member 2
• Protein Family: Linker for activation of T-cells family
• UniProt Gene Name: LAT2
• UniProt Synonym Gene Names: LAB; NTAL; WBS15; WBSCR15; WBSCR5
• UniProt Entry Name: NTAL_HUMAN

NCBI Description

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: lipid raft; plasma membrane

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell activation; B cell receptor signaling pathway; calcium-mediated signaling