KDM6A blocking peptide

KDM6A Blocking Peptide (Center)

• Gene Names: KDM6A; UTX; KABUK2; bA386N14.2
• Synonyms: KDM6A; KDM6A Blocking Peptide (Center); Lysine-specific demethylase 6A; 11411-; Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; UTX; KDM6A blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 797-812 of HUMAN KDM6A
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1401

• Cellular Location: Nucleus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KDM6A blocking peptide

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

NCBI and Uniprot Product Information

• NCBI GI #: 206729942
• NCBI GeneID: 7403
• UniProt Accession #: O15550; Q52LL9; Q5JVQ7
• Molecular Weight: 154,177 Da
• NCBI Official Full Name: Lysine-specific demethylase 6A
• NCBI Official Synonym Full Names: lysine demethylase 6A
• NCBI Official Symbol: KDM6A
• NCBI Official Synonym Symbols: UTX; KABUK2; bA386N14.2
• NCBI Protein Information: lysine-specific demethylase 6A
• UniProt Protein Name: Lysine-specific demethylase 6A
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM6A
• UniProt Synonym Gene Names: UTX
• UniProt Entry Name: KDM6A_HUMAN

NCBI Description

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Description

UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis.

Protein type: Oxidoreductase; EC 1.14.11.-

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone demethylase activity

Biological Process: histone H3-K4 methylation

Disease: Kabuki Syndrome 1; Kabuki Syndrome 2