Kdm6a blocking peptide

Mouse Kdm6a Blocking Peptide (C-term)

• Gene Names: Kdm6a; Utx
• Synonyms: Kdm6a; Mouse Kdm6a Blocking Peptide (C-term); Lysine-specific demethylase 6A; 11411-; Histone demethylase UTX; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Utx; Kdm6a blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 1041-1054 of HUMAN Kdm6a
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1401

• Cellular Location: Nucleus.
• Tissue Location: Expressed in brain, heart and spleen.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Kdm6a blocking peptide

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 122066655
• NCBI GeneID: 22289
• UniProt Accession #: O70546; Q6DI80; Q7TSG4; A2AID2
• Molecular Weight: 157,458 Da
• NCBI Official Full Name: Lysine-specific demethylase 6A
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 6A
• NCBI Official Symbol: Kdm6a
• NCBI Official Synonym Symbols: Utx
• NCBI Protein Information: lysine-specific demethylase 6A
• UniProt Protein Name: Lysine-specific demethylase 6A
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: Kdm6a
• UniProt Synonym Gene Names: Utx
• UniProt Entry Name: KDM6A_MOUSE

Uniprot Description

UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis.

Protein type: Oxidoreductase; EC 1.14.11.-

Cellular Component: histone methyltransferase complex; nucleus

Molecular Function: chromatin binding; chromatin DNA binding; identical protein binding; protein binding

Biological Process: embryonic organ development; heart development; heart morphogenesis; in utero embryonic development; mesodermal cell differentiation; multicellular organism growth; neural tube closure; neural tube development; notochord morphogenesis; regulation of gene expression; respiratory system process; somite rostral/caudal axis specification; Wnt receptor signaling pathway through beta-catenin