HTATSF1 blocking peptide

HTATSF1 Antibody (N-term) Blocking Peptide

• Gene Names: HTATSF1; TATSF1; TAT-SF1; dJ196E23.2
• Synonyms: HTATSF1; HTATSF1 Antibody (N-term) Blocking Peptide; HIV Tat-specific factor 1; Tat-SF1; HTATSF1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human HTATSF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 755

• Cellular Location: Nucleus
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HTATSF1 blocking peptide

Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

NCBI and Uniprot Product Information

• NCBI GI #: 74754346
• NCBI GeneID: 27336
• UniProt Accession #: O43719; Q59G06; Q99730; D3DWG9
• Molecular Weight: 85,853 Da
• NCBI Official Full Name: HIV Tat-specific factor 1
• NCBI Official Synonym Full Names: HIV-1 Tat specific factor 1
• NCBI Official Symbol: HTATSF1
• NCBI Official Synonym Symbols: TATSF1; TAT-SF1; dJ196E23.2
• NCBI Protein Information: HIV Tat-specific factor 1
• UniProt Protein Name: HIV Tat-specific factor 1
• Protein Family: HIV Tat-specific factor
• UniProt Gene Name: HTATSF1
• UniProt Synonym Gene Names: Tat-SF1
• UniProt Entry Name: HTSF1_HUMAN

NCBI Description

The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

TAT-SF1: Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. Belongs to the HTATSF1 family.

Protein type: Spliceosome; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: nucleoplasm; nucleus; snRNP U2

Molecular Function: RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of RNA elongation; regulation of transcription from RNA polymerase II promoter; viral genome replication