HNRNPH2 blocking peptide

HNRNPH2 Antibody (C-term) Blocking peptide

• Gene Names: HNRNPH2; FTP3; HNRPH'; HNRPH2; hnRNPH'
• Synonyms: HNRNPH2; HNRNPH2 Antibody (C-term) Blocking peptide; Heterogeneous nuclear ribonucleoprotein H2; hnRNP H2; FTP-3; Heterogeneous nuclear ribonucleoprotein H'; hnRNP H'; N-terminally processed; FTP3; HNRPH2; HNRNPH2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of HNRNPH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 449

• Cellular Location: Nucleus, nucleoplasm.
• Tissue Location: Expressed ubiquitously.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HNRNPH2 blocking peptide

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

NCBI and Uniprot Product Information

• NCBI GI #: 2500576
• NCBI GeneID: 3188
• UniProt Accession #: P55795; Q9HHA7; A1L400
• Molecular Weight: 49,264 Da
• NCBI Official Full Name: Heterogeneous nuclear ribonucleoprotein H2
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein H2 (H')
• NCBI Official Symbol: HNRNPH2
• NCBI Official Synonym Symbols: FTP3; HNRPH'; HNRPH2; hnRNPH'
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein H2
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein H2
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPH2
• UniProt Synonym Gene Names: FTP3; HNRPH2; hnRNP H2; hnRNP H'
• UniProt Entry Name: HNRH2_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

Uniprot Description

hnRNP H2: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

Protein type: RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; RNA binding

Biological Process: gene expression; nuclear mRNA splicing, via spliceosome