hnRNP A1 Blocking Peptide | hnRNP blocking peptide

hnRNP A1 (E85) Peptide

Cat. Num. AAA3002360

• Gene Names: HNRNPA1; UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1
• Applications: Blocking
• Purity: Synthetic peptide hnRNP A1 (E85). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: hnRNP A1; hnRNP A1 (E85) Peptide; hnRNP core protein A1-like protein; RP11-78J21.1; hnRNP blocking peptide

• Specificity: This peptide can be used with studies using MBS3002359 hnRNP A1 (E85) pAb.
• Purity/Purification: Synthetic peptide hnRNP A1 (E85). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 320

• Applicable Applications for hnRNP blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for hnRNP blocking peptide

HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.

NCBI and Uniprot Product Information

• NCBI GI #: 4504445
• NCBI GeneID: 3178
• NCBI Accession #: NP_002127.1
• NCBI GenBank Nucleotide #: NP_002127.1
• UniProt Accession #: P09651
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein A1 isoform a
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein A1
• NCBI Official Symbol: HNRNPA1
• NCBI Official Synonym Symbols: UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein A1
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein A1
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPA1
• UniProt Synonym Gene Names: HNRPA1; hnRNP A1
• UniProt Entry Name: ROA1_HUMAN

NCBI Description

This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]

Uniprot Description

hnRNP A1: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; RNA splicing; Nuclear export

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; spliceosome; intermediate filament cytoskeleton; membrane; cytoplasm; ribonucleoprotein complex

Molecular Function: protein binding; single-stranded RNA binding; RNA binding; nucleotide binding; single-stranded DNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; mRNA transport; viral reproduction; RNA export from nucleus; RNA splicing; nuclear import; nuclear export; gene expression; mRNA processing

Disease: Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 3; Amyotrophic Lateral Sclerosis 20