HIPK1 blocking peptide

HIPK1 Antibody (C-term) Blocking peptide

• Gene Names: HIPK1; Myak; Nbak2
• Synonyms: HIPK1; HIPK1 Antibody (C-term) Blocking peptide; Homeodomain-interacting protein kinase 1; Nuclear body-associated kinase 2; KIAA0630; MYAK; NBAK2; HIPK1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1210

• Cellular Location: Nucleus. Cytoplasm. Note: Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation
• Tissue Location: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HIPK1 blocking peptide

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

NCBI and Uniprot Product Information

• NCBI GI #: 34395641
• NCBI GeneID: 204851
• UniProt Accession #: Q86Z02; O75125; Q5SQL2; Q5SQL4; Q5SQL5; Q8IYD7; Q8NDN5; Q8NEB6; Q8TBZ1; A6NJ34
• Molecular Weight: 87,302 Da
• NCBI Official Full Name: Homeodomain-interacting protein kinase 1
• NCBI Official Synonym Full Names: homeodomain interacting protein kinase 1
• NCBI Official Symbol: HIPK1
• NCBI Official Synonym Symbols: Myak; Nbak2
• NCBI Protein Information: homeodomain-interacting protein kinase 1
• UniProt Protein Name: Homeodomain-interacting protein kinase 1
• UniProt Gene Name: HIPK1
• UniProt Synonym Gene Names: KIAA0630; MYAK; NBAK2
• UniProt Entry Name: HIPK1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.

Protein type: Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; DYRK family; HIPK subfamily

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: eye development; positive regulation of angiogenesis