Structure
GMI-1271 Biochemical
GMI-1271
Purity
>98% (HPLC)
Synonyms
GMI-1271; GMI1271; Uproleselan sodium; GMI-1271 biochemical
Purity/Purification
>98% (HPLC)
Target
Selectin
Receptor
Selectin
Chemical Name
4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37-Dodecaoxaoctatriacontanamide, N-[2-[[[(1R, 3R, 4R, 5S)-3-[[2-(acetylamino)-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-2-deoxy-b-D-galactopyranosyl]oxy]-4-[(6-deoxy-a-L-galactopyranosyl)oxy]-5-ethylcyclohexyl]carbonyl]amino]ethyl
SMILES
O=C([O-])[C@@H](O[C@@H]1[C@@H](NC(C)=O)[C@H](O[C@H]2[C@H](O[C@H]3[C@H]([C@@H]([C@@H]([C@H](CO)O3)O)O)O)[C@@H](CC)C[C@@H](C(NCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)C2)O[C@H](CO)[C@@H]1O)CC4CCCCC4.[Na+]
Molecular Formula
C60H108N3NaO27
CAS Number
1914993-95-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GMI-1271 biochemical
A novel specific glycomimetic E-Selectin antagonist with Kd of 0.46uM, IC50 of 1.75uM; weakly inhibits L-selectin (IC50=2.9uM) and >10uM for P-selectin; not only mobilizes AML cells out of protective niches but also blocks NF-kB activation and prevents this E-selectin-mediated chemoresistance, thereby enhancing the therapeutic effects of standard chemotherapy; also overcomes MM metastasis and chemoresistance. Blood Cancer Phase 2 Clinical
Product Categories/Family for GMI-1271 biochemical
References
1. Price TT, et al. Mol Cell Oncol. 2016 Jul 26; 4 (4):e1214771.
2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2; 117 (6):1171-1181.
3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123.
4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep; 36 (9):1802-8.
2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2; 117 (6):1171-1181.
3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123.
4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep; 36 (9):1802-8.
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Product Notes
The GMI-1271 (Catalog #AAA3603000) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GMI-1271, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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