GNA11 blocking peptide

GNA11 Antibody(N-term) Blocking peptide

• Gene Names: GNA11; FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2
• Synonyms: GNA11; GNA11 Antibody(N-term) Blocking peptide; Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G-protein subunit alpha-11; Guanine nucleotide-binding protein G(y) subunit alpha; GA11; GNA11 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 359

• Cellular Location: Cell membrane; Lipid-anchor. Cytoplasm. Note: In testicular cells, expressed exclusively in the cytoplasm
• Tissue Location: Expressed in testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNA11 blocking peptide

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

NCBI and Uniprot Product Information

• NCBI GI #: 3041682
• NCBI GeneID: 2767
• UniProt Accession #: P29992; O15109; Q14350; Q6IB00
• Molecular Weight: 42,123 Da
• NCBI Official Full Name: Guanine nucleotide-binding protein subunit alpha-11
• NCBI Official Synonym Full Names: G protein subunit alpha 11
• NCBI Official Symbol: GNA11
• NCBI Official Synonym Symbols: FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-11
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-11
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA11
• UniProt Synonym Gene Names: GA11; G alpha-11; G-protein subunit alpha-11
• UniProt Entry Name: GNA11_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]

Uniprot Description

G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane

Molecular Function: GTPase activity; type 2A serotonin receptor binding

Biological Process: acetylcholine receptor signaling, muscarinic pathway; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; phototransduction, visible light; platelet activation; regulation of action potential; signal transduction

Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii