Western Blot (WB)
(GNA11 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the GNA11 antibody detected the GNA11 protein (arrow).)
Rabbit GNA11 Polyclonal Antibody | anti-GNA11 antibody
GNA11 Antibody (N-term)
Western Blot (WB)
(GNA11 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the GNA11 antibody detected the GNA11 protein (arrow).)
Western Blot (WB)
(GNA11 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the GNA11 antibody detected the GNA11 protein (arrow).)
Gavard, J., et al. J. Biol. Chem. 283(44):29888-29896(2008)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Durchankova, D., et al. Physiol Res 57(2):195-203(2008)
Hildebrand, M.E., et al. J. Biol. Chem. 282(29):21043-21055(2007)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Uniprot Description
G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; regulation of action potential; metabolic process; heart development; pigmentation during development; dopamine receptor, phospholipase C activating pathway; signal transduction; blood coagulation; skeletal development; regulation of melanocyte differentiation
Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii
Research Articles on GNA11
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Product Notes
The GNA11 gna11 (Catalog #AAA9209697) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The GNA11 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat, Pig, Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's GNA11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GNA11 gna11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GNA11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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