FPGS blocking peptide
FPGS Antibody (Center) Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Uniprot Description
FPGS: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. Belongs to the folylpolyglutamate synthase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Cofactor and Vitamin Metabolism - folate biosynthesis; Ligase; EC 6.3.2.17
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion
Molecular Function: tetrahydrofolylpolyglutamate synthase activity
Biological Process: folic acid and derivative metabolic process; folic acid metabolic process; glutamate metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; tetrahydrofolylpolyglutamate biosynthetic process
Research Articles on FPGS
Similar Products
Product Notes
The FPGS fpgs (Catalog #AAA9226462) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FPGS, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
