Flt3 blocking peptide

Mouse Flt3 Antibody (N-term) Blocking Peptide

• Gene Names: Flt3; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
• Synonyms: Flt3; Mouse Flt3 Antibody (N-term) Blocking Peptide; Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase 2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Tyrosine-protein kinase receptor flk-2; CD135; Flk-2; Flt-3; Flt3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1000

• Cellular Location: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen Note: Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity).
• Tissue Location: Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Flt3 blocking peptide

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 803341901
• NCBI GeneID: 14255
• UniProt Accession #: Q00342
• Molecular Weight: 113,496 Da
• NCBI Official Full Name: Receptor-type tyrosine-protein kinase FLT3
• NCBI Official Synonym Full Names: FMS-like tyrosine kinase 3
• NCBI Official Symbol: Flt3
• NCBI Official Synonym Symbols: Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
• NCBI Protein Information: receptor-type tyrosine-protein kinase FLT3
• UniProt Protein Name: Receptor-type tyrosine-protein kinase FLT3
• Protein Family: Flt3 receptor-interacting lectin
• UniProt Gene Name: Flt3
• UniProt Synonym Gene Names: Flk-2; Flt-3; FLK-2; FLT-3
• UniProt Entry Name: FLT3_MOUSE

Uniprot Description

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.

Protein type: Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; TK group; PDGFR family

Cellular Component: cell surface; cytoplasm; cytosol; external side of plasma membrane; nucleus; plasma membrane; protein complex

Molecular Function: glucocorticoid receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: antigen processing and presentation; B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; homeostasis of number of cells within a tissue; leukocyte homeostasis; lymph node development; lymphocyte differentiation; lymphocyte proliferation; lymphoid progenitor cell differentiation; myeloid progenitor cell differentiation; negative regulation of B cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; positive regulation of interferon-alpha production; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of multicellular organism growth; positive regulation of protein amino acid phosphorylation; post-embryonic development; pro-B cell differentiation; pro-T cell differentiation; protein amino acid autophosphorylation; spleen development