FCGRT blocking peptide

FCGRT Antibody (C-term) Blocking Peptide

• Gene Names: FCGRT; FCRN; alpha-chain
• Synonyms: FCGRT; FCGRT Antibody (C-term) Blocking Peptide; IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor; FCRN; FCGRT blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 365

• Function: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effectivehumoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).
• Cellular Location: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein. Endosome membrane
• Tissue Location: Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FCGRT blocking peptide

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

NCBI and Uniprot Product Information

• NCBI GI #: 2497331
• NCBI GeneID: 2217
• UniProt Accession #: P55899; Q5HYM5; Q9HBV7; Q9NZ19
• Molecular Weight: 39,743 Da
• NCBI Official Full Name: IgG receptor FcRn large subunit p51
• NCBI Official Synonym Full Names: Fc fragment of IgG receptor and transporter
• NCBI Official Symbol: FCGRT
• NCBI Official Synonym Symbols: FCRN; alpha-chain
• NCBI Protein Information: IgG receptor FcRn large subunit p51
• UniProt Protein Name: IgG receptor FcRn large subunit p51
• Protein Family: IgG receptor
• UniProt Gene Name: FCGRT
• UniProt Synonym Gene Names: FCRN; FcRn
• UniProt Entry Name: FCGRN_HUMAN

NCBI Description

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Description

FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.

Protein type: Immunoglobulin superfamily; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: plasma membrane

Molecular Function: antigen binding; beta-2-microglobulin binding; IgG binding; IgG receptor activity; peptide antigen binding

Biological Process: antigen processing and presentation