ERN1 blocking peptide
ERN1 Blocking Peptide
Gene Names
ERN2; IRE1b; IRE2p; hIRE2p; IRE1-BETA
Applications
Blocking/Control
Purity
The purity is >90%,tested by HPLC and MS.
Synonyms
ERN1; ERN1 Blocking Peptide; Endoplasmic reticulum (ER) to nucleus signalling 1; Endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signaling 1; ERN 1; Ern1; ERN1_HUMAN; hIRE 1p; hIRE1p; Inositol requiring 1; S. cerevisiae; homolog of; Inositol requiring enzyme 1; Inositol requiring protein 1; inositol-requiring enzyme 1; Inositol-requiring protein 1; IRE 1; IRE 1a; IRE 1P; Ire1 alpha; Ire1-alpha; IRE1a; Ire1alpha; IRE1P; MGC163277; MGC163279; Protein kinase/endoribonuclease; RGD1559716; Serine/threonine protein kinase/endoribonuclease IRE1; ERN1 blocking peptide
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Applicable Applications for ERN1 blocking peptide
Blocking/Control
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ERN1 blocking peptide
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
102,480 Da
NCBI Official Full Name
serine/threonine-protein kinase/endoribonuclease IRE2 isoform b
NCBI Official Synonym Full Names
endoplasmic reticulum to nucleus signaling 2
NCBI Official Symbol
ERN2
NCBI Official Synonym Symbols
IRE1b; IRE2p; hIRE2p; IRE1-BETA
NCBI Protein Information
serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Gene Name
ERN2
UniProt Synonym Gene Names
IRE2; hIRE2p; IRE1b
UniProt Entry Name
ERN2_HUMAN
Uniprot Description
IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.1; Apoptosis; Ribonuclease; Protein kinase, Other; Other group; IRE family
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: protein serine/threonine kinase activity; endonuclease activity; magnesium ion binding; ATP binding; ribonuclease activity
Biological Process: transcription, DNA-dependent; rRNA catabolic process; apoptotic chromosome condensation; mRNA processing; cell cycle arrest; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation
Research Articles on ERN1
Similar Products
Product Notes
The ERN1 ern2 (Catalog #AAA9619930) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ERN1 can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the ERN1 ern2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERN1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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