Ephb3 blocking peptide

Mouse Ephb3 Blocking Peptide (Center)

• Gene Names: Ephb3; Etk2; HEK2; MDK5; Sek4; Cek10; Tyro6; AW456895
• Synonyms: Ephb3; Mouse Ephb3 Blocking Peptide (Center); Ephrin type-B receptor 3; Developmental kinase 5; mDK-5; Tyrosine-protein kinase receptor SEK-4; Etk2; Mdk5; Sek4; Ephb3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 350-362 of HUMAN Ephb3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 993

• Cellular Location: Cell membrane; Single-pass type I membrane protein Cell projection, dendrite
• Tissue Location: Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ephb3 blocking peptide

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

NCBI and Uniprot Product Information

• NCBI GI #: 341940660
• NCBI GeneID: 13845
• UniProt Accession #: P54754; Q62214; Q91YS9
• Molecular Weight: 109,662 Da
• NCBI Official Full Name: Ephrin type-B receptor 3
• NCBI Official Synonym Full Names: Eph receptor B3
• NCBI Official Symbol: Ephb3
• NCBI Official Synonym Symbols: Etk2; HEK2; MDK5; Sek4; Cek10; Tyro6; AW456895
• NCBI Protein Information: ephrin type-B receptor 3
• UniProt Protein Name: Ephrin type-B receptor 3
• Protein Family: Ephrin type-B receptor
• UniProt Gene Name: Ephb3
• UniProt Synonym Gene Names: Etk2; Mdk5; Sek4; mDK-5
• UniProt Entry Name: EPHB3_MOUSE

Uniprot Description

EphB3: a ubiquitous receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members: ephrin-B1 and -B2. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.EphB3 contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.

Protein type: Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Eph family

Cellular Component: integral to plasma membrane

Molecular Function: axon guidance receptor activity; ephrin receptor activity; transmembrane-ephrin receptor activity

Biological Process: angiogenesis; axon guidance; axonal fasciculation; cell migration; central nervous system projection neuron axonogenesis; corpus callosum development; digestive tract morphogenesis; ephrin receptor signaling pathway; palate development; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of axonogenesis; regulation of cell-cell adhesion; regulation of GTPase activity; retinal ganglion cell axon guidance; thymus development; urogenital system development