Epha2 blocking peptide

Mouse Epha2 Antibody (Center) Blocking Peptide

• Gene Names: Epha2; Eck; Myk2; Sek2; Sek-2; AW545284
• Synonyms: Epha2; Mouse Epha2 Antibody (Center) Blocking Peptide; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2; Eck; Myk2; Sek2; Epha2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 977

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein Cell junction, focal adhesion. Note: Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
• Tissue Location: Expressed in the lung, intestine and liver.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Epha2 blocking peptide

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation- induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 341941112
• NCBI GeneID: 13836
• UniProt Accession #: Q03145; Q3UNI2; Q60633; Q62212
• Molecular Weight: 108,852 Da
• NCBI Official Full Name: Ephrin type-A receptor 2
• NCBI Official Synonym Full Names: Eph receptor A2
• NCBI Official Symbol: Epha2
• NCBI Official Synonym Symbols: Eck; Myk2; Sek2; Sek-2; AW545284
• NCBI Protein Information: ephrin type-A receptor 2
• UniProt Protein Name: Ephrin type-A receptor 2
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha2
• UniProt Synonym Gene Names: Eck; Myk2; Sek2
• UniProt Entry Name: EPHA2_MOUSE

Uniprot Description

EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice.

Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; Eph family

Cellular Component: cell surface; focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: axial mesoderm formation; blood vessel development; blood vessel endothelial cell proliferation during sprouting angiogenesis; blood vessel morphogenesis; bone remodeling; cell migration; defense response to Gram-positive bacterium; DNA damage response, signal transduction resulting in induction of apoptosis; ephrin receptor signaling pathway; inflammatory response; keratinocyte differentiation; mammary gland epithelial cell proliferation; negative regulation of angiogenesis; negative regulation of chemokine production; negative regulation of cytokine production; negative regulation of protein kinase B signaling cascade; neural tube development; neuron differentiation; notochord cell development; notochord formation; notochord morphogenesis; osteoblast differentiation; osteoclast differentiation; protein kinase B signaling cascade; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; skeletal development; vasculogenesis