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Eif2ak4 blocking peptide

Mouse Eif2ak4 Antibody (C-term) Blocking Peptide

Gene Names
Eif2ak4; GCN2; MGCN2; 2610011M03
Synonyms
Eif2ak4; Mouse Eif2ak4 Antibody (C-term) Blocking Peptide; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; mGCN2; Gcn2; Kiaa1338; Eif2ak4 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1648
Tissue Location
Expressed in liver (at protein level). Widely expressed, with the highest levels in the liver and the brain Isoform 4 is expressed in brain followed by testis and liver and isoform 3 is expressed only in brain
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Eif2ak4 blocking peptide
Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
59,991 Da
NCBI Official Full Name
eIF-2-alpha kinase GCN2
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2 alpha kinase 4
NCBI Official Symbol
Eif2ak4
NCBI Official Synonym Symbols
GCN2; MGCN2; 2610011M03
NCBI Protein Information
eIF-2-alpha kinase GCN2
UniProt Protein Name
eIF-2-alpha kinase GCN2
Protein Family
UniProt Gene Name
Eif2ak4
UniProt Synonym Gene Names
mGCN2
UniProt Entry Name
E2AK4_MOUSE

Uniprot Description

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: Translation; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; PEK family; GCN2 subfamily

Cellular Component: intracellular; polysome

Molecular Function: eukaryotic translation initiation factor 2alpha kinase activity; protein binding; protein serine/threonine kinase activity; tRNA binding

Biological Process: cellular response to amino acid starvation; cellular response to starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translation initiation in response to stress; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process

Research Articles on Eif2ak4

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Product Notes

The Eif2ak4 eif2ak4 (Catalog #AAA9221033) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Eif2ak4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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