EHD1 blocking peptide

EHD1 Antibody (C-term) Blocking peptide

• Gene Names: EHD1; PAST; PAST1; H-PAST; HPAST1
• Synonyms: EHD1; EHD1 Antibody (C-term) Blocking peptide; EH domain-containing protein 1; PAST homolog 1; hPAST1; Testilin; PAST; PAST1; EHD1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of EHD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 534

• Cellular Location: Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Preferentially associates with tubular recycling endosomes. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes
• Tissue Location: Highly expressed in testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EHD1 blocking peptide

Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth.

NCBI and Uniprot Product Information

• NCBI GI #: 18202945
• NCBI GeneID: 10938
• UniProt Accession #: Q9H4M9; O14611; Q2M3Q4; Q9UNR3
• Molecular Weight: 60,627 Da
• NCBI Official Full Name: EH domain-containing protein 1
• NCBI Official Synonym Full Names: EH domain containing 1
• NCBI Official Symbol: EHD1
• NCBI Official Synonym Symbols: PAST; PAST1; H-PAST; HPAST1
• NCBI Protein Information: EH domain-containing protein 1
• UniProt Protein Name: EH domain-containing protein 1
• Protein Family: EH domain-containing protein
• UniProt Gene Name: EHD1
• UniProt Synonym Gene Names: hPAST1
• UniProt Entry Name: EHD1_HUMAN

NCBI Description

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

EHD1: Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.

Protein type: Vesicle; Calcium-binding

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: early endosome membrane; endosome membrane; lipid particle; membrane; plasma membrane; recycling endosome membrane

Molecular Function: protein binding; Rab GTPase binding

Biological Process: blood coagulation; cholesterol homeostasis; cilium biogenesis; endocytic recycling; endocytosis; intracellular protein transport; neurite development; protein homooligomerization