EDC3 blocking peptide

EDC3 Blocking Peptide (Center)

Gene Names

EDC3; YJDC; LSM16; MRT50; YJEFN2

Synonyms

EDC3; EDC3 Blocking Peptide (Center); Enhancer of mRNA-decapping protein 3; LSM16 homolog; YjeF N-terminal domain-containing protein 2; YjeF_N2; hYjeF_N2; YjeF domain-containing protein 1; LSM16; YJDC; YJEFN2; EDC3 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 234-247 of HUMAN EDC3

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

508

Cellular Location

Cytoplasm, P-body. Note: Processing bodies (PB)

Tissue Location

Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level) Also expressed in brain and mammary gland

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EDC3 blocking peptide

Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis.

NCBI and Uniprot Product Information

NCBI GI #

19923613

NCBI GeneID

80153

NCBI Accession #

NP_079359.2

NCBI GenBank Nucleotide #

NM_025083.3

UniProt Accession #

Q96F86; Q9H797; B3KPH0; D3DW61

Molecular Weight

56,078 Da

NCBI Official Full Name

enhancer of mRNA-decapping protein 3

NCBI Official Synonym Full Names

enhancer of mRNA decapping 3

NCBI Official Symbol

EDC3

NCBI Official Synonym Symbols

YJDC; LSM16; MRT50; YJEFN2

NCBI Protein Information

enhancer of mRNA-decapping protein 3

UniProt Protein Name

Enhancer of mRNA-decapping protein 3

Protein Family

Enhancer of mRNA-decapping protein

UniProt Gene Name

EDC3

UniProt Synonym Gene Names

LSM16; YJDC; YJEFN2; YjeF_N2; hYjeF_N2

UniProt Entry Name

EDC3_HUMAN

NCBI Description

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]

Uniprot Description

EDC3: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. Belongs to the EDC3 family.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: cytosol; membrane

Molecular Function: identical protein binding; mRNA binding; protein binding

Biological Process: cytoplasmic mRNA processing body assembly; deadenylation-independent decapping

Disease: Mental Retardation, Autosomal Recessive 50

Research Articles on EDC3

1. In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentration.

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Product Notes

The EDC3 edc3 (Catalog #AAA9228929) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EDC3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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EDC3 blocking peptide