Rabbit anti-Human CB1 Polyclonal Antibody | anti-CB1 antibody

CB1, ID (CNR1, CNR, Cannabinoid receptor 1, CANN6) (APC)

Cat. Num. AAA6281069

• Gene Names: CNR1; CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: CB1; Polyclonal Antibody; ID (CNR1; CNR; Cannabinoid receptor 1; CANN6) (APC); CNR1; CANN6; anti-CB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CB1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CB1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 161-187 in the central region of human CB1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in 293 cell line lysates (35ug/lane) using 033235. This demonstrates that 033235 detected the CB1 protein (arrow).)

Related Product Information for anti-CB1 antibody

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq].

Product Categories/Family for anti-CB1 antibody

Antibodies; Receptors

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Van Laere, K., et al. J. Nucl. Med. 51(9):1413-1417(2010). 3. Larrinaga, G., et al. Histol. Histopathol. 25(9):1133-1138(2010). 4. Monteleone, P., et al. J Clin Psychopharmacol 30(4):441-445(2010). 5. Thors, L., et al. PLoS ONE 5 (8), E12275 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 38683844
• NCBI GeneID: 1268
• NCBI Accession #: NP_057167.2
• NCBI GenBank Nucleotide #: NM_016083.5
• UniProt Accession #: P21554; Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0; B2R9T4; E1P512
• Molecular Weight: 45,874 Da
• NCBI Official Full Name: cannabinoid receptor 1 isoform a
• NCBI Official Synonym Full Names: cannabinoid receptor 1
• NCBI Official Symbol: CNR1
• NCBI Official Synonym Symbols: CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
• NCBI Protein Information: cannabinoid receptor 1
• UniProt Protein Name: Cannabinoid receptor 1
• Protein Family: CB1 cannabinoid receptor-interacting protein
• UniProt Gene Name: CNR1
• UniProt Synonym Gene Names: CNR; CB-R; CB1
• UniProt Entry Name: CNR1_HUMAN

NCBI Description

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Uniprot Description

CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: growth cone; intracellular membrane-bound organelle; integral to plasma membrane; axon; plasma membrane

Molecular Function: cannabinoid receptor activity; drug binding

Biological Process: response to nicotine; maternal process involved in pregnancy; negative regulation of fatty acid beta-oxidation; regulation of synaptic transmission, glutamatergic; positive regulation of apoptosis; response to morphine; positive regulation of acute inflammatory response to antigenic stimulus; response to lipopolysaccharide; sensory perception of pain; glucose homeostasis; negative regulation of blood pressure; negative regulation of dopamine secretion; response to nutrient; aging; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; axonal fasciculation; negative regulation of action potential; response to cocaine; regulation of synaptic transmission, GABAergic; memory; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; regulation of insulin secretion; positive regulation of blood pressure