DNMT3L blocking peptide

Dnmt3L Antibody (C-term) Blocking Peptide

• Synonyms: Dnmt3L; Dnmt3L Antibody (C-term) Blocking Peptide; DNA (cytosine-5)-methyltransferase 3-like; DNMT3L; DNMT3L blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human Dnmt3L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 386

• Cellular Location: Nucleus.
• Tissue Location: Expressed at low levels in several tissues including testis, ovary, and thymus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DNMT3L blocking peptide

Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.

NCBI and Uniprot Product Information

• NCBI GI #: 334302913
• NCBI GeneID: 29947
• UniProt Accession #: Q9UJW3; Q9BUJ4; E9PB42
• Molecular Weight: 43,670 Da
• NCBI Official Full Name: DNA (cytosine-5)-methyltransferase 3-like
• NCBI Official Synonym Full Names: DNA methyltransferase 3 like
• NCBI Official Symbol: DNMT3L
• NCBI Protein Information: DNA (cytosine-5)-methyltransferase 3-like
• UniProt Protein Name: DNA (cytosine-5)-methyltransferase 3-like
• Protein Family: DNA (cytosine-5)-methyltransferase
• UniProt Gene Name: DNMT3L
• UniProt Entry Name: DNM3L_HUMAN

NCBI Description

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.