DNAJB4 blocking peptide

DNAJB4 Blocking Peptide (C-Term)

• Gene Names: DNAJB4; DjB4; HLJ1; DNAJW
• Synonyms: DNAJB4; DNAJB4 Blocking Peptide (C-Term); DnaJ homolog subfamily B member 4; Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein; DNAJW; HLJ1; DNAJB4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 236-248 of HUMAN DNAJB4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 337

• Cellular Location: Cytoplasm. Cell membrane. Note: Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645
• Tissue Location: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DNAJB4 blocking peptide

Probable chaperone.

NCBI and Uniprot Product Information

• NCBI GI #: 8928155
• NCBI GeneID: 11080
• UniProt Accession #: Q9UDY4; Q13431; B2R824
• Molecular Weight: 37,807 Da
• NCBI Official Full Name: DnaJ homolog subfamily B member 4
• NCBI Official Synonym Full Names: DnaJ heat shock protein family (Hsp40) member B4
• NCBI Official Symbol: DNAJB4
• NCBI Official Synonym Symbols: DjB4; HLJ1; DNAJW
• NCBI Protein Information: dnaJ homolog subfamily B member 4
• UniProt Protein Name: DnaJ homolog subfamily B member 4
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJB4
• UniProt Synonym Gene Names: DNAJW; HLJ1; HSP40 homolog; Heat shock protein 40 homolog
• UniProt Entry Name: DNJB4_HUMAN

NCBI Description

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

DNAJB4: Probable chaperone. Homodimer. The C-terminal section interacts with the C- terminal tail of OPRM1. Interacts also with SDIM1. By heat shock. Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function: chaperone binding; protein binding

Biological Process: response to heat; response to unfolded protein