DMRT2 blocking peptide

DMRT2 Blocking Peptide (N-Term)

Synonyms

DMRT2; DMRT2 Blocking Peptide (N-Term); Doublesex- and mab-3-related transcription factor 2; Doublesex-like 2 protein; DSXL-2; DSXL2; DMRT2 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 242-256 of HUMAN DMRT2

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

561

Cellular Location

Nucleus

Tissue Location

Expressed in testis, kidney and skeletal muscle

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DMRT2 blocking peptide

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

334302783

NCBI GeneID

10655

UniProt Accession #

Q9Y5R5; Q9NPG6; Q9NQR6; B1ANC0; B9EGJ1

Molecular Weight

36,884 Da

NCBI Official Full Name

Doublesex- and mab-3-related transcription factor 2

NCBI Official Synonym Full Names

doublesex and mab-3 related transcription factor 2

NCBI Official Symbol

DMRT2

NCBI Protein Information

doublesex- and mab-3-related transcription factor 2

UniProt Protein Name

Doublesex- and mab-3-related transcription factor 2

Protein Family

Doublesex- and mab-3-related transcription factor

UniProt Gene Name

DMRT2

UniProt Synonym Gene Names

DSXL2; DSXL-2

UniProt Entry Name

DMRT2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]

Uniprot Description

DMRT2: belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9p24.3

Cellular Component: nucleus

Molecular Function: protein homodimerization activity; transcription factor activity

Biological Process: sex differentiation

Similar Products

Product Notes

The DMRT2 dmrt2 (Catalog #AAA9230359) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DMRT2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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DMRT2 blocking peptide