Dbf4 blocking peptide

Dbf4 (I18) Peptide

Cat. Num. AAA3002514

• Gene Names: DBF4; ASK; CHIF; DBF4A; ZDBF1
• Applications: Blocking
• Purity: Synthetic peptide Dbf4 (I18). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Dbf4; Dbf4 (I18) Peptide; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1; DBF4; ASK; DBF4A; ZDBF1; Dbf4 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002513 Dbf4 (I18) pAb.
• Purity/Purification: Synthetic peptide Dbf4 (I18). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 674

• Applicable Applications for Dbf4 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Dbf4 blocking peptide

The Dbf4/Cdc7 protein kinase is essential for the activation of replication origins during S phase. Cdc7-Dbf4 efficiently phosphorylates several proteins that are required for the initiation of DNA replication, including five of the six minichromosome maintenance (Mcm) proteins and the p180 subunit of DNA polymerase alpha-primase. This protein complex consists of the catalytic subunit Cdc7 associating with the regulatory and activating subunit Dbf4, and the kinase activity of the complex is regulated throughout the cell cycle mainly by fluctuating levels of Dbf4. Cdc7 is consistently expressed throughout the cell cycle, while the expression of Dbf4 is absent during G1 phase and accumulates during S and G2 phases. The anaphase-promoting complex rapidly degrades Dbf4 at the time of chromosome segregation, and the stability of Dbf4 remains low during pre-Start G1 phase.

NCBI and Uniprot Product Information

• NCBI GI #: 5729734
• NCBI GeneID: 10926
• NCBI Accession #: NP_006707.1
• NCBI GenBank Nucleotide #: NP_006707.1
• UniProt Accession #: Q9UBU7
• NCBI Official Full Name: protein DBF4 homolog A isoform 1
• NCBI Official Synonym Full Names: DBF4 zinc finger
• NCBI Official Symbol: DBF4
• NCBI Official Synonym Symbols: ASK; CHIF; DBF4A; ZDBF1
• NCBI Protein Information: protein DBF4 homolog A
• UniProt Protein Name: Protein DBF4 homolog A
• Protein Family: DDK kinase regulatory
• UniProt Gene Name: DBF4
• UniProt Synonym Gene Names: ASK; DBF4A; ZDBF1
• UniProt Entry Name: DBF4A_HUMAN

Uniprot Description

DBF4: DBF4

Protein type: Cell cycle regulation; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: nucleoplasm

Molecular Function: nucleic acid binding; zinc ion binding; enzyme activator activity

Biological Process: positive regulation of catalytic activity; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle