CXCR2 blocking peptide

CXCR2 Peptide

Cat. Num. AAA543389

• Gene Names: CCR2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
• Applications: Immunodepletion, Immunocompetition
• Synonyms: CXCR2; CXCR2 Peptide; C-X-C chemokine receptor type 2; CD 182; CD182 antigen; CDw128b; Chemokine (CXC) receptor 2; CMKAR2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL8R B; IL8R2; IL8RA; Interleukin 8 receptor; beta; type 2 antibody; CXCR2 blocking peptide

• Form/Format: Antigenic Blocking Peptide
• Concentration: Quantity: 250 ug; Volume: 100 ul (varies by lot)
• Sequence Length: 374

• Applicable Applications for CXCR2 blocking peptide: Immunodepletion, Immunocompetition
• Application Notes: Confocal Microscopy||1:200; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Western Blot: 1:500
• Immunogen: Synthetic Peptide
• Expression: Up-regulated by CREB5
• Determinant: C-epitope
• Molecular Function: G-Protein coupled receptor, Transducer, chemokine receptor activity
• Structure: Binds to HIV-1 Tat and interacts with ARRB3
• Subcellular Location: Cell membrane; Multi-pass membrane protein
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for CXCR2 blocking peptide

Antigenic Blocking Peptide IL8 Receptor beta Antibody C-epitope
Receptor for CCL2, CCL7 and CCL13 chemokines. Transudces a signal via increasing intracellular calcium ion levels.

NCBI and Uniprot Product Information

• NCBI GI #: 1168965
• NCBI GeneID: 729230
• UniProt Accession #: P41597; Q4VBL2; A0AVQ3; B2RMT0
• Molecular Weight: 41,064 Da
• NCBI Official Full Name: C-C chemokine receptor type 2
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 2
• NCBI Official Symbol: CCR2
• NCBI Official Synonym Symbols: CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
• NCBI Protein Information: C-C chemokine receptor type 2
• UniProt Protein Name: C-C chemokine receptor type 2
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CCR2
• UniProt Synonym Gene Names: CMKBR2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; MCP-1-R
• UniProt Entry Name: CCR2_HUMAN

NCBI Description

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

Uniprot Description

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; cell surface; cytoplasm; cytosol; dendrite; endosome; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity; protein kinase binding

Biological Process: aging; blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; defense response to bacterium; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; fat cell differentiation; forebrain development; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of axon extension; negative regulation of cell migration; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis by virus; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to ionizing radiation; response to lipopolysaccharide; response to wounding