COPZ1 blocking peptide

COPZ1 Antibody (N-term) Blocking Peptide

• Gene Names: COPZ1; COPZ; CGI-120; HSPC181; zeta-COP; zeta1-COP
• Synonyms: COPZ1; COPZ1 Antibody (N-term) Blocking Peptide; Coatomer subunit zeta-1; Zeta-1-coat protein; Zeta-1 COP; COPZ; COPZ1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of COPZ1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 177

• Cellular Location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for COPZ1 blocking peptide

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 48428830
• NCBI GeneID: 22818
• UniProt Accession #: P61923; Q549N6; Q9Y3C3; B4DDX8; B4DHZ0; F8VS17; F8VWL5
• Molecular Weight: 18,374 Da
• NCBI Official Full Name: Coatomer subunit zeta-1
• NCBI Official Synonym Full Names: coatomer protein complex subunit zeta 1
• NCBI Official Symbol: COPZ1
• NCBI Official Synonym Symbols: COPZ; CGI-120; HSPC181; zeta-COP; zeta1-COP
• NCBI Protein Information: coatomer subunit zeta-1
• UniProt Protein Name: Coatomer subunit zeta-1
• Protein Family: Coatomer
• UniProt Gene Name: COPZ1
• UniProt Synonym Gene Names: COPZ; Zeta-1 COP
• UniProt Entry Name: COPZ1_HUMAN

NCBI Description

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Description

COPZ1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the adaptor complexes small subunit family.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q13.2-q13.3

Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi membrane; transport vesicle

Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to ER