CHRNA4 blocking peptide

CHRNA4 Blocking Peptide (N-Term)

• Gene Names: CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
• Synonyms: CHRNA4; CHRNA4 Blocking Peptide (N-Term); Neuronal acetylcholine receptor subunit alpha-4; NACRA4; CHRNA4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 196-208 of HUMAN CHRNA4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 627

• Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHRNA4 blocking peptide

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

NCBI and Uniprot Product Information

• NCBI GI #: 1351848
• NCBI GeneID: 1137
• UniProt Accession #: P43681; Q4JGR7; Q4VAQ5; Q4VAQ6
• Molecular Weight: 60,994 Da
• NCBI Official Full Name: Neuronal acetylcholine receptor subunit alpha-4
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic alpha 4 subunit
• NCBI Official Symbol: CHRNA4
• NCBI Official Synonym Symbols: EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
• NCBI Protein Information: neuronal acetylcholine receptor subunit alpha-4
• UniProt Protein Name: Neuronal acetylcholine receptor subunit alpha-4
• Protein Family: Neuronal acetylcholine receptor
• UniProt Gene Name: CHRNA4
• UniProt Synonym Gene Names: NACRA4
• UniProt Entry Name: ACHA4_HUMAN

NCBI Description

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Description

nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cell soma; dendrite; external side of plasma membrane; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity

Biological Process: B cell activation; behavioral response to nicotine; calcium ion transport; cognition; DNA repair; membrane depolarization; neurological system process; neuromuscular synaptic transmission; regulation of action potential; regulation of dopamine secretion; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission, cholinergic

Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To