CENPW blocking peptide
CENPW Peptide
NCBI and Uniprot Product Information
Uniprot Description
CENPW: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Belongs to the CENPW family.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 6q22.32
Cellular Component: kinetochore; nucleoplasm; nuclear matrix; nucleolus; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; protein heterodimerization activity
Biological Process: mitosis; nucleosome assembly; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; cell division; mitotic cell cycle; chromosome organization and biogenesis; chromosome segregation
Research Articles on CENPW
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Product Notes
The CENPW cenpw (Catalog #AAA153895) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CENPW can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). CENPW peptide is used for blocking the activity of CENPW antibody. Researchers should empirically determine the suitability of the CENPW cenpw for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CENPW, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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