CD1C blocking peptide

CD1C Antibody (C-term) Blocking peptide

• Gene Names: CD1C; R7; CD1; CD1A; BDCA1
• Synonyms: CD1C; CD1C Antibody (C-term) Blocking peptide; T-cell surface glycoprotein CD1c; CD1c; CD1C blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of CD1C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 333

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes
• Tissue Location: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CD1C blocking peptide

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

NCBI and Uniprot Product Information

• NCBI GI #: 143811371
• NCBI GeneID: 911
• UniProt Accession #: P29017; Q5TDJ7; Q6IAS4; Q9UMM0; Q9UN96
• Molecular Weight: 37,654 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD1c
• NCBI Official Synonym Full Names: CD1c molecule
• NCBI Official Symbol: CD1C
• NCBI Official Synonym Symbols: R7; CD1; CD1A; BDCA1
• NCBI Protein Information: T-cell surface glycoprotein CD1c
• UniProt Protein Name: T-cell surface glycoprotein CD1c
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD1C
• UniProt Entry Name: CD1C_HUMAN

NCBI Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Uniprot Description

CD1C: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; glycolipid binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response; T cell activation during immune response