CCR10 blocking peptide

CCR10 Antibody (N-term) Blocking peptide

• Gene Names: CCR10; GPR2
• Synonyms: CCR10; CCR10 Antibody (N-term) Blocking peptide; C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR-10; G-protein coupled receptor 2; GPR2; CCR10 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of CCR10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 362

• Cellular Location: Cell membrane; Multi-pass membrane protein.
• Tissue Location: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CCR10 blocking peptide

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

NCBI and Uniprot Product Information

• NCBI GI #: 62298314
• NCBI GeneID: 2826
• UniProt Accession #: P46092; Q4V749; Q6T7X2; Q9NZG2
• Molecular Weight: 38,416 Da
• NCBI Official Full Name: C-C chemokine receptor type 10
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 10
• NCBI Official Symbol: CCR10
• NCBI Official Synonym Symbols: GPR2
• NCBI Protein Information: C-C chemokine receptor type 10
• UniProt Protein Name: C-C chemokine receptor type 10
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR10
• UniProt Synonym Gene Names: GPR2; C-C CKR-10; CC-CKR-10; CCR-10
• UniProt Entry Name: CCR10_HUMAN

NCBI Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Uniprot Description

CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q21.1-q21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity