Rabbit anti-Human CCR10 Polyclonal Antibody | anti-CCR10 antibody

CCR10 Antibody

Cat. Num. AAA7051821

• Gene Names: CCR10; GPR2
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: CCR10; Polyclonal Antibody; CCR10 Antibody; C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR-10; G-protein coupled receptor 2; GPR2; anti-CCR10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 362

• Applicable Applications for anti-CCR10 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human C-C chemokine receptor type 10 protein (314-362AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7051821 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of A549 cells using MBS7051821 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Western Blot (WB)

(Western BlotPositive WB detected in: A549 whole cell lysate,HepG2 whole cell lysateAll lanes: CCR10 antibody at 2.7ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 39 KDaObserved band size: 39 KDa)

Related Product Information for anti-CCR10 antibody

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

NCBI and Uniprot Product Information

• NCBI GI #: 156104886
• NCBI GeneID: 2826
• NCBI Accession #: NP_057686.2
• NCBI GenBank Nucleotide #: NM_016602.2
• UniProt Accession #: P46092; Q4V749; Q6T7X2; Q9NZG2
• Molecular Weight: 38,416 Da
• NCBI Official Full Name: C-C chemokine receptor type 10
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 10
• NCBI Official Symbol: CCR10
• NCBI Official Synonym Symbols: GPR2
• NCBI Protein Information: C-C chemokine receptor type 10
• UniProt Protein Name: C-C chemokine receptor type 10
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR10
• UniProt Synonym Gene Names: GPR2; C-C CKR-10; CC-CKR-10; CCR-10

NCBI Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Uniprot Description

CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity