CAMLG blocking peptide

CAMLG Blocking Peptide

Cat. Num. AAA9628318

• Gene Names: CAMLG; CAML
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: CAMLG; CAMLG Blocking Peptide; calcium modulating cyclophilin ligand; calcium modulating ligand; Calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; MGC163197; CAMLG blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for CAMLG blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CAMLG blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4502559
• NCBI GeneID: 819
• NCBI Accession #: NP_001736.1
• NCBI GenBank Nucleotide #: NM_001745.3
• UniProt Accession #: P49069; A1L3Y3
• Molecular Weight: 32,953 Da
• NCBI Official Full Name: calcium signal-modulating cyclophilin ligand
• NCBI Official Synonym Full Names: calcium modulating ligand
• NCBI Official Symbol: CAMLG
• NCBI Official Synonym Symbols: CAML
• NCBI Protein Information: calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; cyclophilin B-binding protein
• UniProt Protein Name: Calcium signal-modulating cyclophilin ligand
• Protein Family: Calcium signal-modulating cyclophilin ligand
• UniProt Gene Name: CAMLG
• UniProt Synonym Gene Names: CAML; CAML
• UniProt Entry Name: CAMLG_HUMAN

NCBI Description

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

Uniprot Description

CAMLG: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q23

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; cell adhesion molecule binding

Biological Process: receptor recycling; epidermal growth factor receptor signaling pathway; viral reproduction; defense response; signal transduction