Camk1d blocking peptide

Mouse Camk1d Blocking Peptide (N-term)

• Gene Names: Camk1d; CKLiK; mCKLiK; CaMKIdelta; A630059D12Rik; E030025C11Rik
• Synonyms: Camk1d; Mouse Camk1d Blocking Peptide (N-term); Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM-KI delta; CaMKI delta; CaM kinase ID; CaMKI-like protein kinase; CKLiK; mCKLiK; Camk1d blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 385

• Cellular Location: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic. Nuclear upon activation.
• Tissue Location: Expressed ubiquitously with high levels in brain and low levels in kidney. Isoform 2 is highly expressed in brain compared to other tissues. In hematopoietic cell lines predominant expression was detected in T and EC cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Camk1d blocking peptide

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine- induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity). Isoform 1 but not isoform 2 activates CREB1.

NCBI and Uniprot Product Information

• NCBI GI #: 56404603
• NCBI GeneID: 227541
• UniProt Accession #: Q8BW96; Q3U450; Q80W64; Q8BWI7
• Molecular Weight: 42,135 Da
• NCBI Official Full Name: Calcium/calmodulin-dependent protein kinase type 1D
• NCBI Official Synonym Full Names: calcium/calmodulin-dependent protein kinase ID
• NCBI Official Symbol: Camk1d
• NCBI Official Synonym Symbols: CKLiK; mCKLiK; CaMKIdelta; A630059D12Rik; E030025C11Rik
• NCBI Protein Information: calcium/calmodulin-dependent protein kinase type 1D
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type 1D
• Protein Family: Calcium/calmodulin-dependent protein kinase
• UniProt Gene Name: Camk1d
• UniProt Synonym Gene Names: CaM-KI delta; CaMKI delta; CKLiK; mCKLiK
• UniProt Entry Name: KCC1D_MOUSE

Uniprot Description

CAMK1D: a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; CAMK group; CAMK1 family

Cellular Component: cytoplasm; nucleus

Molecular Function: calmodulin-dependent protein kinase activity

Biological Process: activation of CREB transcription factor; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of phagocytosis; regulation of dendrite development