Calcipressin-1 Blocking Peptide | RCAN1 blocking peptide

Calcipressin-1 Peptide

Cat. Num. AAA3005822

• Gene Names: RCAN1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
• Applications: Blocking
• Purity: Synthetic peptide Calcipressin-1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Calcipressin-1; Calcipressin-1 Peptide; Calcipressin 1; Calcipressin1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1; RCAN1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005821 Calcipressin-1 pAb.
• Purity/Purification: Synthetic peptide Calcipressin-1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 252

• Applicable Applications for RCAN1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for RCAN1 blocking peptide

Calcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

NCBI and Uniprot Product Information

• NCBI GI #: 33620725
• NCBI GeneID: 1827
• NCBI Accession #: NP_004405.3
• NCBI GenBank Nucleotide #: NP_004405.3
• UniProt Accession #: P53805
• NCBI Official Full Name: calcipressin-1 isoform a
• NCBI Official Synonym Full Names: regulator of calcineurin 1
• NCBI Official Symbol: RCAN1
• NCBI Official Synonym Symbols: CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
• NCBI Protein Information: calcipressin-1
• UniProt Protein Name: Calcipressin-1
• Protein Family: Calcipressin
• UniProt Gene Name: RCAN1
• UniProt Synonym Gene Names: ADAPT78; CSP1; DSC1; DSCR1; MCIP1
• UniProt Entry Name: RCAN1_HUMAN

NCBI Description

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Description

RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity

Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction