BAHD1 blocking peptide

BAHD1 Antibody (C-term) Blocking Peptide

• Synonyms: BAHD1; BAHD1 Antibody (C-term) Blocking Peptide; Bromo adjacent homology domain-containing 1 protein; BAH domain-containing protein 1; KIAA0945; BAHD1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human BAHD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 780

• Cellular Location: Nucleus. Chromosome. Note: Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BAHD1 blocking peptide

Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3.

NCBI and Uniprot Product Information

• NCBI GI #: 152040006
• NCBI GeneID: 22893
• UniProt Accession #: Q8TBE0; Q8NDF7; Q9Y2F4
• Molecular Weight: 84,314 Da
• NCBI Official Full Name: Bromo adjacent homology domain-containing 1 protein
• NCBI Official Synonym Full Names: bromo adjacent homology domain containing 1
• NCBI Official Symbol: BAHD1
• NCBI Protein Information: bromo adjacent homology domain-containing 1 protein
• UniProt Protein Name: Bromo adjacent homology domain-containing 1 protein
• Protein Family: BAHD acyltransferase
• UniProt Gene Name: BAHD1
• UniProt Synonym Gene Names: KIAA0945; BAH domain-containing protein 1
• UniProt Entry Name: BAHD1_HUMAN

Uniprot Description

BAHD1: Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IL28A, IL28B and IL29. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: chromatin; chromatin silencing complex; nucleoplasm

Molecular Function: chromatin binding; protein binding

Biological Process: chromatin silencing; heterochromatin formation; negative regulation of transcription, DNA-dependent