B4GALT4 blocking peptide

B4GALT4 Antibody (Center) Blocking Peptide

• Gene Names: B4GALT4; B4Gal-T4; beta4Gal-T4
• Synonyms: B4GALT4; B4GALT4 Antibody (Center) Blocking Peptide; Beta-1;4-galactosyltransferase 4; Beta-1;4-GalTase 4; Beta4Gal-T4; b4Gal-T4; 241-; UDP-Gal:beta-GlcNAc beta-1;4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1;4-galactosyltransferase 4; N-acetyllactosamine synthase; Nal synthase; Lactotriaosylceramide beta-1;4-galactosyltransferase; Beta-N-acetylglucosaminyl-glycolipid beta-1;4-galactosyltransferase; B4GALT4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 344

• Cellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note: Trans cisternae of Golgi stack
• Tissue Location: High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for B4GALT4 blocking peptide

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

NCBI and Uniprot Product Information

• NCBI GI #: 13123971
• NCBI GeneID: 8702
• UniProt Accession #: O60513; Q68D68; Q9BSW3; Q9C078
• Molecular Weight: 40,041 Da
• NCBI Official Full Name: Beta-1,4-galactosyltransferase 4
• NCBI Official Synonym Full Names: beta-1,4-galactosyltransferase 4
• NCBI Official Symbol: B4GALT4
• NCBI Official Synonym Symbols: B4Gal-T4; beta4Gal-T4
• NCBI Protein Information: beta-1,4-galactosyltransferase 4
• UniProt Protein Name: Beta-1,4-galactosyltransferase 4
• Protein Family: Beta-1,4-galactosyltransferase
• UniProt Gene Name: B4GALT4
• UniProt Synonym Gene Names: Beta-1,4-GalTase 4; Beta4Gal-T4; b4Gal-T4
• UniProt Entry Name: B4GT4_HUMAN

NCBI Description

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

B4GALT4: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Belongs to the glycosyltransferase 7 family.

Protein type: EC 2.4.1.90; Glycan Metabolism - keratan sulfate biosynthesis; Transferase; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.275

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: Golgi membrane

Molecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity

Biological Process: keratan sulfate biosynthetic process; membrane lipid metabolic process