Western Blot (WB)
(B4GALT4 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the B4GALT4 antibody detected the B4GALT4 protein (arrow).)
Rabbit anti-Human B4GALT4 Polyclonal Antibody | anti-B4GALT4 antibody
B4GALT4 Antibody (Center)
Western Blot (WB)
(B4GALT4 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the B4GALT4 antibody detected the B4GALT4 protein (arrow).)
Western Blot (WB)
(B4GALT4 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the B4GALT4 antibody detected the B4GALT4 protein (arrow).)
(beta4GalT) genes. They encode type II membrane-bound glycoproteins
that appear to have exclusive specificity for the donor substrate
UDP-galactose; all transfer galactose in a beta1,4 linkage to
similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a
distinct function in the biosynthesis of different glycoconjugates
and saccharide structures. As type II membrane proteins, they have
an N-terminal hydrophobic signal sequence that directs the protein
to the Golgi apparatus and which then remains uncleaved to function
as a transmembrane anchor. By sequence similarity, the beta4GalTs
form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and
beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme
encoded by this gene appears to mainly play a role in glycolipid
biosynthesis. Two alternatively spliced transcript variants have
been found for this gene.
Guo, S., et al. Glycobiology 11(10):813-820(2001)
Suzuki, Y., et al. Genome Res. 11(5):677-684(2001)
Amado, M., et al. Biochim. Biophys. Acta 1473(1):35-53(1999)
Fan, Y., et al. Sci. China, C, Life Sci. 42(4):337-345(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
B4GALT4: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Belongs to the glycosyltransferase 7 family.
Protein type: Glycan Metabolism - keratan sulfate biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.90; EC 2.4.1.275; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 3q13.3
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: N-acetyllactosamine synthase activity; metal ion binding; galactosyltransferase activity
Biological Process: keratan sulfate metabolic process; cellular protein metabolic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; membrane lipid metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Similar Products
Product Notes
The B4GALT4 b4galt4 (Catalog #AAA9209078) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 91-117. The B4GALT4 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's B4GALT4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the B4GALT4 b4galt4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "B4GALT4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
