ATP12A blocking peptide

ATP12A Antibody (Center) Blocking Peptide

• Gene Names: ATP12A; HK; #945; ATP1AL1
• Synonyms: ATP12A; ATP12A Antibody (Center) Blocking Peptide; Potassium-transporting ATPase alpha chain 2; Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump; ATP1AL1; ATP12A blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human ATP12A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1039

• Cellular Location: Membrane; Multi-pass membrane protein.
• Tissue Location: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ATP12A blocking peptide

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 212287925
• NCBI GeneID: 479
• UniProt Accession #: P54707; Q13816; Q13817; Q16734; Q5W035; Q8N5U2
• Molecular Weight: 116,053 Da
• NCBI Official Full Name: Potassium-transporting ATPase alpha chain 2
• NCBI Official Synonym Full Names: ATPase H+/K+ transporting non-gastric alpha2 subunit
• NCBI Official Symbol: ATP12A
• NCBI Official Synonym Symbols: HK; #945; ATP1AL1
• NCBI Protein Information: potassium-transporting ATPase alpha chain 2
• UniProt Protein Name: Potassium-transporting ATPase alpha chain 2
• Protein Family: Potassium-transporting ATPase
• UniProt Gene Name: ATP12A
• UniProt Synonym Gene Names: ATP1AL1
• UniProt Entry Name: AT12A_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

ATP12A: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Energy Metabolism - oxidative phosphorylation; Transporter, ion channel; EC 3.6.3.10; Membrane protein, integral; Membrane protein, multi-pass; Hydrolase

Chromosomal Location of Human Ortholog: 13q12.12|13q12.1-q12.3

Cellular Component: hydrogen:potassium-exchanging ATPase complex; intracellular membrane-bound organelle; plasma membrane

Molecular Function: hydrogen:potassium-exchanging ATPase activity; sodium:potassium-exchanging ATPase activity

Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import