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APC blocking peptide

APC Antibody (Center) Blocking Peptide

Gene Names
APC; GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
Synonyms
APC; APC Antibody (Center) Blocking Peptide; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 25; DP25; APC blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
2843
Cellular Location
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note: Associated with the microtubule network at the growing distal tip of microtubules Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane
Tissue Location
Expressed in a variety of tissues.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for APC blocking peptide
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
324
UniProt Accession #
Molecular Weight
300,439 Da
NCBI Official Full Name
Adenomatous polyposis coli protein
NCBI Official Synonym Full Names
APC, WNT signaling pathway regulator
NCBI Official Symbol
APC
NCBI Official Synonym Symbols
GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
NCBI Protein Information
adenomatous polyposis coli protein
UniProt Protein Name
Adenomatous polyposis coli protein
Protein Family
UniProt Gene Name
APC
UniProt Synonym Gene Names
DP2.5; Protein APC
UniProt Entry Name
APC_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Uniprot Description

APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q21-q22

Cellular Component: beta-catenin destruction complex; catenin complex; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; kinetochore; lamellipodium; lateral plasma membrane; nucleoplasm; nucleus; plasma membrane; tight junction

Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity

Biological Process: cell cycle arrest; cell fate specification; cell migration; cell structure disassembly during apoptosis; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of microtubule depolymerization; pattern specification process; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; regulation of attachment of spindle microtubules to kinetochore; regulation of cell differentiation; regulation of microtubule-based process; response to DNA damage stimulus; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Cancer; Hepatocellular Carcinoma

Research Articles on APC

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Product Notes

The APC apc (Catalog #AAA9224169) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "APC, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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