AP4M1 blocking peptide

AP4M1 Antibody (Center) Blocking Peptide

• Gene Names: AP4M1; MU-4; CPSQ3; SPG50; MU-ARP2
• Synonyms: AP4M1; AP4M1 Antibody (Center) Blocking Peptide; AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; Mu4-adaptin; mu4; MUARP2; AP4M1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 453

• Cellular Location: Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells
• Tissue Location: Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AP4M1 blocking peptide

Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP.

NCBI and Uniprot Product Information

• NCBI GI #: 145559442
• NCBI GeneID: 9179
• UniProt Accession #: O00189; Q8WV65; Q9UHK9; D6W5U1
• Molecular Weight: 49,977 Da
• NCBI Official Full Name: AP-4 complex subunit mu-1
• NCBI Official Synonym Full Names: adaptor related protein complex 4 mu 1 subunit
• NCBI Official Symbol: AP4M1
• NCBI Official Synonym Symbols: MU-4; CPSQ3; SPG50; MU-ARP2
• NCBI Protein Information: AP-4 complex subunit mu-1
• UniProt Protein Name: AP-4 complex subunit mu-1
• Protein Family: AP-4 complex
• UniProt Gene Name: AP4M1
• UniProt Synonym Gene Names: MUARP2; mu-ARP2; mu4
• UniProt Entry Name: AP4M1_HUMAN

NCBI Description

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]

Uniprot Description

AP4M1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. Belongs to the adaptor complexes medium subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: AP-type membrane coat adaptor complex; Golgi trans cisterna; trans-Golgi network; trans-Golgi network membrane

Molecular Function: protein binding; transporter activity

Biological Process: Golgi to endosome transport; intracellular protein transport; vesicle-mediated transport

Disease: Spastic Paraplegia 50, Autosomal Recessive