ANGPTL4 blocking peptide

ANGPTL4 Antibody (Center) Blocking Peptide

• Gene Names: ANGPTL4; NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158
• Synonyms: ANGPTL4; ANGPTL4 Antibody (Center) Blocking Peptide; Angiopoietin-related protein 4; Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein; HFARP; ARP4; PGAR; ANGPTL4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human ANGPTL4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 406

• Cellular Location: Secreted. Secreted, extracellular space, extracellular matrix Note: The unprocessed form interacts with the extracellular matrix This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity).
• Tissue Location: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ANGPTL4 blocking peptide

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 25008123
• NCBI GeneID: 51129
• UniProt Accession #: Q9BY76; Q53HQ6; Q53HU1; Q6UXN0; Q9HBV4; Q9NZU4; Q9Y5B3; A8MY84; B4E089; D6W670; F5H0I2
• Molecular Weight: 26,853 Da
• NCBI Official Full Name: Angiopoietin-related protein 4
• NCBI Official Synonym Full Names: angiopoietin like 4
• NCBI Official Symbol: ANGPTL4
• NCBI Official Synonym Symbols: NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158
• NCBI Protein Information: angiopoietin-related protein 4
• UniProt Protein Name: Angiopoietin-related protein 4
• Protein Family: Angiopoietin-related protein
• UniProt Gene Name: ANGPTL4
• UniProt Synonym Gene Names: ARP4; HFARP; PGAR; HFARP
• UniProt Entry Name: ANGL4_HUMAN

NCBI Description

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Uniprot Description

ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Protein type: Secreted; Inhibitor; Extracellular matrix; Apoptosis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: enzyme inhibitor activity; identical protein binding; protein binding

Biological Process: negative regulation of apoptosis; negative regulation of lipoprotein lipase activity; positive regulation of angiogenesis

Disease: Plasma Triglyceride Level Quantitative Trait Locus